The second International Conference for EBHC Developers and Teachers, held in Palermo, Sicily, focused on “Signposting the Future in EBHC.” The event gathered hundreds of international delegates to discuss emerging trends, challenges, and innovations in evidence-based healthcare. This edition provided a platform for participants to share insights, strengthen global collaborations, and chart pathways for the future of EBHC teaching and implementation. The historic city of Palermo served as a dynamic backdrop for this milestone event.